Ketone ester administration could decrease methacholine responses. Over half of the people that have asthma are obese. They do not respond to standard therapies but new research is proving positive for asthma treatment using ketones. This is an innovative step towards a cost-effective, efficient, and safe strategy that could target those that are obese with asthma in the future.

People that are obese with asthma find they are hospitalized more than other asthma sufferers. Weight loss is a recommendation to reduce the effects of obesity on asthma. Surgical intervention is an option. Fifteen percent of people can sustain a ten percent weight loss for twelve months by changing their diet. Fewer can sustain their weight loss for five years, which is a serious concern for those with asthma.

The research carried out focused on how ketones could relieve the asthma systems in obese individuals. Genetic and diet-induced mice were used with normal weight controls. They also tested numerous methods of applying ketones. Natural generation of ketones was induced through a ketogenic diet in some mice and others were placed on a low-fat diet. The remainder were given the sustained energy supplement in their food.

All mice models had ketone bodies in their system with less sensitivity to trigger airway constriction, which is used to diagnose asthma. Ketone supplementation is safe and used by people throughout the world.

Terry Kitagawa, the Nutrition Product Development Manager at Aleva, said “Ketone supplementation strategies can be used to promote therapeutic ketosis, speeding up the positive effects of the ketogenic diet and fasting. Avela reduces the need to diet while counting calories and without having to make a serious lifestyle adjustment.”

Terry Kitagawa went on to say “Ketosis is amazing but it's not easy to achieve. Many of the ingredients on the market are not palatable, causing gastric issues, and can be expensive. We supply Avela™ Natural (R)-1,3 Butanediol, which is affordable, palatable, and an effective ketogenic ingredient to increase BHB levels effectively. Avela kick starts the ketosis benefits, increasing endurance, energy, and clarity.”

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