As a leader in antibody-drug conjugate (ADC) development, Creative Biolabs launched new ADC characterization service in order to provide high-quality services and various assay formats for different analytes of an ADC.
Pharmacokinetics (PK) studies provide critical information regarding the behavior of a drug in circulation and its ultimate form after extensive in vivo metabolism. Results from PK studies often serve as guidelines for clinical trials designs, especially in the development of an antibody-drug conjugate (ADC). Due to the heterogeneous nature of ADCs, multiple analytes have to be assessed to reveal the ADC PK characteristics, making these studies more complex.
“Our team offers various formats of quantification assays to determine the in vivo pharmacokinetics profiles of an ADC. Total and conjugated antibodies, free and conjugated drugs, as well as catabolites are three key parameters determined by analyzing plasma/serum samples collected from animal experiments. ” A scientist from Creative Biolabs said that.
“We not only provide modified ELISA assays for total and conjugated antibody detection, but also provide advanced LC-MS analysis approaches to assay for conjugated drug, free drug, and catabolites ”
With a full understanding of the complexity of ADC PK studies, Creative Biolabs provides both standard and customized PK analysis services for ADC development, including DAR Characterization, ADC Tissue Distribution, ADC Metabolism and Clearance.
About Creative Biolabs
Established in 2004, Creative Biolabs is highly specialized in advanced adc antibody biochemistry and engineering. With more than a decade of exploration and expansion, the current research and service capacity covers the entire new drug discovery and development pipeline, ranging from early discovery, preclinical evaluations, cGMP manufacturing, to clinical trials. As an international cooperation, Creative Biolab established offices all around the globe with more than 200 well-trained full-time scientists and technicians, who work closely with customers and research partners to develop new medicines for a better, healthier world.