Even all the ingredients are very effective to treat the wrinkles and to give a glow to your faceis a cream and is applied normally like any other cream. Before applying it, make sure that your face is washed and dry. Then take a small quantity and apply it all Derma Vibrance over your face as well as neck. The more you rub the cream, the more it will be absorbed but rub it very gently. The regular usage of the cream is a must and you have to apply it twice daily. If you are a makeup lover and use to apply makeup daily then you can apply the makeup over this cream but give at least 30 minutes to this cream so that it leaves the outer surface and pours deeply inside. In case, you find any rashes or even irritation on your skin then it is advised to stop it immediately. http://drozforskolin.org/derma-vibrance-reviews/