Enzymes are portentous molecules that are present in cells, to perform catalytic functions in number of biochemical reactions in the body. Enzymes aids in biochemical reactions without get used up in the biochemical reactions. Deficiency of the enzymes in the body lead to malfunction of the body organs and there by systems that lead to Lysosomal Storage Diseases (LSD). Enzyme replacement therapy is the method of medical management, in which healthcare professionals replaces an enzyme in patients who are deficient of particular enzyme with artificial enzymes. Enzyme replacement therapy done by administering patient with an intravenous infusion or oral administration of enzyme containing preparations. Enzyme replacement therapy is available for few disease like fabry disease, hunter syndrome, gaucher disease, digestive disease and pomp syndrome etc. Enzyme replacement therapies are meant for increasing the concentration of enzymes but not for correcting underline cause of the diseases.

Enzyme Replacement Therapy Market: Drivers and Restraints

Global enzyme replacement therapy market is continue to witness positive growth owing to ease of regulations for approving enzyme replacement therapies by designating Orphan Drug Status (ODS) and advantages associated with ERT like fewer side effects, wider availability would expected to fuel demand for enzyme replacement therapy market over the forecast period. The market for enzyme replacement therapy driven by financial assistance to the patients by several nations’ foundations, non-profit organizations like National Gaucher Foundation’s care and care+ plus programmes, patient access network etc., which makes enzyme replacement therapy accessible to the patients. Potential beneficial treatment outcomes, ease of access to the treatment in developed healthcare setups, and pharma companies initiative to support the patient groups will help to bolster growth of enzyme replacement therapy market. However, inconvenience associated with parenteral IV infusion, cost of therapy or insurance concerns, fewer side effects, and black box warnings on few products may hamper the growth of the enzyme replacement therapy market over the forecast period.

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Enzyme Replacement Therapy Market: Segmentation

Global enzyme replacement therapy market has been segmented on the basis of enzyme type, clinical indication, route of administration, end user, and region.

Based on the enzyme type, the global enzyme replacement therapy market is segmented into the following:

Agalsidase Beta

Imiglucerase

Velaglucerase Alfa

Taliglucerase

Alglucosidase Alfa

Laronidase

Idursulfase

Galsulfase

Pegademase

Pancreatic Enzymes

Others

Based on the clinical indication, the global enzyme replacement therapy market is segmented into the following:

Fabry Disease

Gaucher Disease

Pompe Disease

Scheie Syndrome

Hunter Disease

Maroteaux-Lamy Syndrome

Severe Combined Immunodeficiency Disease (SCID)

Digestion

Others

Based on the route of administration, the global enzyme replacement therapy market is segmented into the following:

Parenteral Route

Oral

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Based on the end user, the global enzyme replacement therapy market is segmented into the following:

Hospitals

Clinics/Infusion Centers

Homecare Settings

Enzyme Replacement Therapy Market: Overview

Global enzyme replacement therapy market is dominated with handful of players who are offering these products. Market for enzyme replacement therapy is consistently witnessing newer challenges as patients are increasingly witnessing side effects associated with treatment regimen. Players in the enzyme replacement therapy market coming up with several patient centric initiatives in order to assist the patients in terms of offering free therapies, patient education regarding disease and continuous medical education to the healthcare professionals regarding the disease and its management.

Enzyme Replacement Therapy Market: Region-wise Outlook

Geographically, enzyme replacement therapy market is segmented into regions viz. North America, Latin America, Western Europe, Eastern Europe, Asia-Pacific excluding Japan, Japan, Middle East and Africa. North America and Europe will remain key markets for enzyme replacement therapy market. North America and Europe region are expected to witness strong growth owing to drug availability, favourable reimbursement policies and advanced healthcare infrastructure.

Enzyme Replacement Therapy Market: Key Players

Some players in enzyme replacement therapy market include Genzyme Corporation, Shire plc., Pfizer Inc., BioMarin Pharmaceutical, Inc., Sigma-Tau Pharmaceuticals, Inc., Essential Pharmaceuticals Limited, Merck KGa, AbbVie Inc. to name a few.

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