Neprilysin inhibitors cause an increase in levels of natriuretic peptides, which are important in maintaining fluid and sodium balance through natriuresis, diuresis, and vasodilation. This reduces blood pressure and effectively treats heart failure. Neprilysin can be used in combination with other medications to enhance the treatment of heart failure. Thus, anti-neprilysin medications are used for treatment of hypertension, heart failure, renal diseases, and others. Entresto is the only brand available in the market manufactured by Novartis International AG. Entresto is combination of sacubitril/valsartan that is the drug combination of angiotensin receptor neprilysin inhibitor (ARNI) respectively. Sacubitril/valsartan is used in place of an angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blocker (ARB) and in conjunction treatment when it is not working for heart disease patients.
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Anti-Neprilysin Market - Impact of Coronavirus (Covid-19) Pandemic
The pandemic of COVID-19 has significantly augmented demand for several drugs. The spread of coronavirus is also negatively impacting the sales of companies, whose product demand highly depend on selective disease treatments such as anti-neprilysin, which is majorly used for treatment of heart diseases. Furthermore, cardiovascular disease patients are highly at risk of being affected by COVID-19 infection due to fragile heart conditions. The COVID-19 infects the lungs, drop blood oxygen levels at first and secondly, the inflammatory effects of the virus itself will cause the blood pressure to drop. In such cases, the heart must beat faster and harder to supply oxygen to major organs due to which the survival rates of individuals with ailing heart conditions become very less even with proper medications.
The anti-neprilysin market is estimated to be valued at US$ 1,109.25 million in 2020 and is expected to exhibit a CAGR of 4.6% during the forecast period (2020-2027).
Increasing prevalence of cardiovascular disorders and product approvals are expected to boost growth of the anti-neprilysin market
Anti-neprilysin drug Entresto is expected to be useful to treat other diseases such as hypertension, Alzheimer’s disease, stroke, atrial fibrillation, renal diseases, and some other diseases are under research with anti-neprilysin treatment. Therefore, increasing prevalence of such diseases is expected to boost the anti-neprilysin market growth over the forecast period. For instance, according to the World Health Organization (WHO) report of September 2019, around 1.13 billion people worldwide suffered from hypertension, most living in low- and middle-income countries in 2019. Moreover, rising prevalence of hypertension increases the risk of heart attack, stroke, and kidney damage, as well as other health problems.
Furthermore, the anti-neprilysin market is expected to witness significant growth in the near future, owing to increasing product approvals by regulatory bodies. For instance, in February 2015, Novartis International AG announced that the U.S. Food and Drug Administration (FDA) granted priority review for LCZ696, an investigational medicine for the treatment of heart failure with reduced ejection fraction (HFrEF). The designation is intended to accelerate the review of therapies that offer a significant improvement in the safety or effectiveness of the treatment, prevention or diagnosis of a serious condition.
Anti-Neprilysin Market - Restraints
However, frequent drug recalls is expected to hamper the anti-neprilysin market growth over the forecast period. Frequent drug recalls are caused due to various reasons such as faulty packaging and inconsistency in formation among others. For instance, in July 2018, Novartis issued a voluntary recall of Entresto Hospital Unit Dose (HUD) tablets. This recall was issued, as the packaging of these products were not child-resistant, which could pose a risk of harm if the tablets are swallowed by children.
Anti-Neprilysin Market – Regional Analysis
North America accounted for the largest share in the anti-neprilysin market in 2019, owing to definitive agreements between companies in the region. For instance, in February 2016, Cigna Corporation and Aetna Inc. entered into an outcome-based studies agreement with the pharmaceutical company Novartis for the drug Entresto, which was approved by the U.S. Food and Drug Administration for the treatment of heart failure with reduced ejection fraction. In this agreement, Cigna's pharmacists and nurses are involved in providing focused clinical care, which includes monitoring a customer’s medication adherence, side effects, and drug interactions, reviewing lab values, and collaborating with customers’ physicians when adjustments are needed.
Furthermore, the increasing number of clinical trials of anti-neprilysin drugs are expected to accelerate the anti-neprilysin market growth in the near future. For instance, in June 2017, Pharmaleads, a France-based pharmaceutical company, announced positive results in a first Phase I trial for its DENKI peptide PL265 to treat chronic neuropathic pain. Moreover, the biotech company announced that its second clinical stage peptide, PL265, has successfully cleared a Phase I single-ascending dose (SAD) trial, allowing the company to move its compound towards the next stage of clinical development.
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Anti-Neprilysin Market - Competitive Landscape
Key players operating in the anti-neprilysin market include Bioprojet SCR, Novartis International AG, Pharmaleads SA, Theravance Biopharma Inc., Cipla Limited, and Oceanic Pharmachem Pvt. Ltd.
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