Fibroblast activation protein (FAP) is a serine protein that is selectively expressed in pathologic sites in the adults making it a target specific site for many therapeutic agents. Fibroblast activation protein (FAP) is expressed during tissue remodeling stage in embryonic development. However, in adults, fibroblast activation protein (FAP) is expressed in specific sites like cancer, arthritis, inflammation, injury, pulmonary fibrosis, etc. Fibroblast activation protein is widely believed to be expressed on stromal fibroblasts of epithelial cancer cells and promotes cancer cell growth and metastasis. The specificity of fibroblast activation protein offers potential to represent as a new drug target in the diagnosis and treatment of cancer. Various clinical trials are being conducted to assess the potential of treating cancer by inhibiting the fibroblast activation protein. Cancer cells are often very sensitive to growth factors. Development of cancer growth impeders such as fibroblast activation protein (FAP) inhibitors can provide promising results in cancer management.

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The rising incidence of cancer around the world has spurred the use of fibroblast activation protein (FAP) inhibitors as they assist in preventing the proliferation of carcinogenic cells. In a report, titled “Fibroblast Activation Protein Inhibitors Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2016 – 2024,” Transparency Market Research (TMR) presents refined forecasts about the market’s trajectory between 2016 and 2024. The factors driving or restraining the global FAP inhibitors market are studied in detail as well.

As per the National Cancer Institute, over 1,685,210 new cases of cancer are expected to be diagnosed by the end of 2016 in the U.S. alone. The most common types of cancer affecting an increasing number of people are prostate cancer, breast cancer, rectum cancer, colorectal cancer, bladder cancer, lung and bronchus cancer, kidney and renal pelvis cancer, colon cancer, pancreatic cancer, and leukemia. Of these, the colorectal cancer has emerged as the third most common type of cancers affecting millions around the world. According to the World Cancer Research Fund International, each year approximately 1.5 million new cases of colorectal cancer are reported.

This alarming rise of cancer around the world has compelled government and international agencies to invest in the discovery of novel therapeutics and methods to treat colorectal cancer. The increasing prevalence of various cancers globally, is the prime factor fuelling the demand for anti-cancer drugs. In addition to this, the market is significantly gaining from the improvement in advanced therapeutic approaches such as radiotherapy, immunotherapy, targeted therapies, and chemotherapy. Although not much progress is made in the field of FAP inhibitors discovery for the treatment of various types of cancer, it still possesses substantial opportunities for the research and development in the near future.

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Because FAP inhibitors hold huge opportunities in the treatment of cancer, various research and development programs are being conducted to determine their effective uses. Besides these, various agencies have also conducted several clinical trials to assess the efficacy of FAP inhibitors such as talabostat in the treatment of cancer. Another popular approach being implemented for the development of fibroblast activation protein inhibitor is the use of monoclonal antibodies. However, these approaches are yet to be used extensively in a clinical setting, mainly owing to lack of effective actions.

Regionally, North America, Latin America, Western Europe, Eastern Europe, the Middle East and Africa, and Asia Pacific constitute the key segments of the global FAP inhibitors market. TMR estimates the size of the market across all its regional segments in the report. The socio-economic and other factors influencing the market across all these regions are studied in detail as well.


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