6. Multiple Debuffs for Ultimate Synergy: Chain Reactions
The true power of multiple debuffs is their ability to set up chain reactions. By applying several debuffs in succession, you can create an ideal environment for your team’s Ultimate Skills to shine. Understanding the timing and interplay between these debuffs will ensure you hit the highest possible damage while minimizing enemy retaliation.

How to Use:
Combine Vulnerability, Weaken, Chill, Stun, and Slow in quick succession before launching your Ultimate Skills to ensure that the enemy is completely overwhelmed and incapable of defending themselves.
Example:
You first Weaken a boss to lower its resistances, then apply Vulnerability for increased damage. Chill the boss to slow its movements and Stun it to prevent retaliation. With the enemy fully incapacitated, your team can now unleash a powerful Ultimate, causing maximum damage without interruption.
Conclusion: Master the Art of Debuff Synergy
The ability to stack multiple debuffs in Diablo 4 is an essential tactic for maximizing the damage potential of your Ultimate Skills. By applying Vulnerability, Weaken, Chill, Slow, and Stun in the right order, you create opportunities to hit enemies harder, more efficiently, and with less risk of retaliation. Combining these debuffs with Ultimate Skills will ensure that your team’s efforts lead to overwhelming victories, allowing you to conquer even the most challenging Uber Bosses, Nightmare Dungeons, and endgame content in Diablo 4.

When it comes to ultimate synergy, timing, preparation, and coordination are key — apply debuffs strategically to dominate the battlefield and unleash the full potential of your Ultimate Skills.

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