MRRS adds "Frontier Pharma: Breast Cancer – First-in-Class Innovation Clustered Around Growth Factor Signalling Processes" latest studies, published in November 2016. It is a professional and in-depth study.

Summary
The breast cancer pipeline is the largest in the pharmaceutical industry, with 1,050 products in active development across all stages. The range of mechanisms of action employed by these compounds is also highly diverse, especially in comparison to the existing market landscape. The degree and proportion of breakthrough innovations in this pipeline is exceptional – GBI Research analysis identified 333 first-in-class programs in the breast cancer pipeline, acting on 251 first-in-class molecular targets. This accounts for some 39% of all products with a disclosed molecular target, and is reflective of the high degree of innovation in this indication. This has far-reaching strategic implications for all market participants, as despite the high attrition rate in breast cancer, it is highly likely many of the first-in-class products will reach the market over the coming decade and, will have the opportunity to transform the clinical and commercial landscape.

Potential driving factors behind this market include a very large and growing patient pool, a well-established disease market with a number of strong unmet needs, and the strong understanding of the disease pathophysiology that has developed over the last decade, facilitating the development of novel compounds that may fill the unmet needs.

Table of Contents
3 The Case for Innovation in the Breast Cancer Market 5
3.1 Growing Opportunities for Biologic Products 5
3.2 Diversification of Molecular Targets 5
3.3 Innovative First-in-Class Product Developments Remain Attractive 5
3.4 Changes in Clinical and Commercial Environment to be More Favorable to Products Targeting Niche Patient Populations and Indications 5
3.5 Sustained Innovation 6
3.6 Report Guidance 6
4 Clinical and Commercial Landscape 8
4.1 Disease Overview 8
4.2 Epidemiology 8
4.3 Disease Symptoms 9
4.4 Etiology 9
4.4.1 Age and Gender 9
4.4.2 Genetic Makeup 9
4.4.3 Environmental 10
4.5 Pathophysiology 10
4.5.1 Tumor Initiation and Aberrant Cell Proliferation and Survival 10
4.5.2 Tumor Metabolic Shift 11
4.5.3 Tumor Progression, Micro-environment Alteration and Angiogenesis 12
4.5.4 Cancer Stem Cells 13
4.6 Diagnosis 13
4.7 Prognosis and Disease Staging 14
4.7.1 Classification 15
4.8 Introduction to Breast Cancer Treatments 16
4.9 Surgery and Radiation Therapy 17
4.10 Overview of Marketed Products for Breast Cancer 17
4.10.1 Chemotherapy 18
4.10.2 Hormonal Therapies 19
4.10.3 Targeted Therapies 19
4.11 Treatment Algorithm 21
4.12 Current Unmet Need in Breast Cancer Market 23
5 Assessment of Pipeline Product Innovation 25
5.1 Breast Cancer Pipeline by Phase, Molecule Type and Molecular Target 25
5.2 First-in-Class Pipeline Programs 29
6 Signaling Network, Disease Causation and Innovation Alignment 36......

List of Tables and Figures 
Table 1: Tumor, regional lymph Node and Metastasis Staging, 2010–2013 14
Table 2: US, Disease Stage at Diagnosis and Five-year Relative Survival (%), 2013 14
Table 3: Breast Cancer Histopathological and Molecular Classification 15
Table 4: Key Features and Pipeline Activity of FGFR3 41
Table 5: Key Features and Pipeline Activity of FGFR4 42
Table 6: Pipeline Programs Targeting FGFR4 42
Table 7: Key Features and Pipeline Activity of HER3 43
Table 8: Key Features and Pipeline Activity of PDPK1 44
Table 9: Key Features and Pipeline Activity of Akt1 46
Table 10: Key Features and Pipeline Activity of Akt2 46
Table 11: Key Features and Pipeline Activity of Akt3 47
Table 12: Key Features and Pipeline Activity of PI3K-alpha 48.....

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