The global downstream processing market size is expected to reach USD 69.6 billion by 2028, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 15.9% from 2021 to 2028. The capacity requirements during the development of biologic drugs have changed over the past few years, wherein the demand for manufacturing high-volume products has shifted to developing small-volume, high potency products. This creates new avenues for single-use technologies.

A rise in applications of downstream processing for the manufacture of biopharmaceuticals is expected to bring growth opportunities to the market. This has also led to an increase in strategic deals and development in the market. For instance, in February 2021, Evozyne, LLC collaborated with a leading rare disorders drug manufacturer for the manufacture and marketing of novel biopharmaceuticals for immune modulation.

As adoption of small-scale, single-use systems for process development and downstream processing is already high, evolutionary changes are expected in the area of single-use technologies for manufacturing small-volume, highly potent drugs. The development of novel film chemistries, closed systems, automation in clinical-scale single-use systems, and smart sensors are some noteworthy advancements in the field.

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In January 2021, Thermo Fisher Scientific announced that it supported 250 projects for COVID-19 therapy as well as vaccine production in 2020. The company leverages its CDMO capabilities as well as its bioprocess consumables and equipment offerings for these projects. It has also partnered with Singapore and the U.S. government to expand its vaccine and therapy development capacities. Similar efforts have been made by EMD Millipore, Cytiva, Pall Biotech, and other companies to use their bioprocess offerings for COVID-19 therapeutics development.

The number of CMOs in the market for downstream processing has increased as outsourcing helps pharmaceutical manufacturers reduce the high initial capital investment and procedure costs. CMOs help drug manufacturers in optimizing downstream purification, in addition to other processes such as cell culture preparation, chromatography, mixing, concentration, process monitoring, and disposable technologies.

A rise in R&D activities pertaining to advanced bioprocess technologies has resulted in the adoption of continuous downstream processing systems for multicomponent separations, perfusion chromatography systems, high-throughput process development, and high-resolution membrane systems. This has led to an increase in the need for improving bioprocessing technologies for addressing the purification bottleneck.

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Top Key Players & Market Share Insights:

Companies are increasingly focusing on the development of new products for downstream processing. For instance, in June 2020, Corning Incorporated launched the Corning X-SERIES cell processing platform. The X-SERIES products include X-LAB System, X-WASH System, and X-MINI Selection Kit for efficient cell separation and purification. The X-SERIES cell processing platform finds applications in immune cell therapy, bioprocess, personalized medicine, and gene cell therapy fields. This helped expand the company’s portfolio in the market. Some of the prominent players in the downstream processing market include:

Merck KGaA

Sartorius Stedim Biotech S.A

GE Healthcare

Thermo Fisher Scientific Inc.

Danaher Corporation

Repligen

3M Company

Boehringer Ingelheim International GmbH

Corning Corporation

Lonza Group Ltd

Dover Corporation

Ashai Kasei

Ferner PLC

Eppendorf AG


About Grand View Research



Grand View Research is a market research and consulting company that offers market research reports, syndicated and customized reports. The company is headquartered in San Francisco, California. It offers client engagement for business consulting and market intelligence from various domains. The clientele is based across various countries with queries coming from more than 50 industries worldwide.

Grand View Research helps its clients to make informed decisions by helping them understand current trends and scenarios. Every year Grand View Research accomplishes more than 300 multi-country market studies to optimize consulting for clients.


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