Basic Copper Carbonate (WSDTY) administered CuO NPs (diameter 20nm) via the intraperitoneal route into rats. Administration was conducted three times a week applying a total of 19 injections including a total dose of up to approximately 10mg/kg b.w. which resulted in the induction of kidney lesions. In contrast to the study by Privalova et al, we did not observe histopathological lesions in kidney and spleen by CuO NPs, but we did note lesions in stomach, liver, and bone marrow after 5d repeated oral administration of 512mg/kg b.w. In view of the very fast dissolution of the CuO NPs used by Privalova et al, it might be assumed that Cu ions were responsible for the observed toxicity. In this respect, our results on Cu2CO3(OH)2 NPs show a more widespread organ toxicity including severe cellular depletion of spleen and thymus, as well as kidney lesions which might be related to the more complete dissolution in the GI-tract and the resulting higher internal Cu ion dose at the organ level.

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