Diabetic Complications–Innovative and Diverse Neuropathies, Nephropathy and Retinopathies Pipelines


Posted December 14, 2016 by Shirley

Frontier Pharma: Diabetic Complications – Innovative and Diverse Neuropathies, Nephropathy and Retinopathies Pipelines Demonstrate Shift Towards Disease Modifying Therapies is a professional and in-depth study.
 
MRRS adds "Frontier Pharma: Diabetic Complications – Innovative and Diverse Neuropathies, Nephropathy and Retinopathies Pipelines Demonstrate Shift Towards Disease Modifying Therapies" latest studies, published in November 2016. It is a professional and in-depth study.

Summary
Diabetes is a common long-term condition that can lead to a range of disparate and serious complications. It is a lifelong, multi-systemic condition that affects a number of integral organs. Diabetes has a rapidly increasing prevalence – it currently affects 10% of adults globally, and is estimated to become the seventh-leading cause of death by 2030.

The lack of absolute treatment for the condition and the difficulty in maintaining constant glycemic control, even following adequate treatment, can result in a range of complications. The three main indication groups are diabetic nephropathy, which is a progressive condition caused by damage to the capillaries and kidneys glomeruli as a result of diabetes; diabetic retinopathy, which is defined as damage to the retina as a result of high blood sugar; and a range of diabetic neuropathies, a group of conditions in which nerve damage is caused as a result of diabetes mellitus.

Table of Contents
1 Table of Contents 2
2 Executive Summary 5
2.1 Significant Unmet Needs in Diabetic Complications Market 5
2.2 High Proportion of First-in-Class Innovation Offers Promise in Diabetic Complications 5
2.3 Deal Activity Varies with First-in-Class Status 5
3 The Case for Innovation 6
3.1 Growing Opportunities for Biologic Products 7
3.2 Diversification of Molecular Targets 7
3.3 Innovative First-in-Class Product Development Remains Attractive 7
3.4 Regulatory and Reimbursement Policy Shifts Favor First-in-Class Product Innovation 8
3.5 Sustained Innovation 8
3.6 GBI Research Report Guidance 8
4 Clinical and Commercial Landscape 10
4.1 Diabetes Mellitus Overview 10
4.2 Diabetic Neuropathies 11
4.2.1 Disease Overview 11
4.2.2 Signs and Symptoms 11
4.2.3 Epidemiology and Etiology 12
4.2.4 Pathophysiology 12
4.2.5 Diagnosis and Staging 12
4.2.6 Prognosis 13
4.2.7 Treatment Options 13
4.3 Diabetic Nephropathy 14
4.3.1 Disease Overview 14
4.3.2 Sign and Symptoms 14
4.3.3 Epidemiology and Etiology 14
4.3.4 Pathophysiology 14
4.3.5 Diagnosis and Staging 14
4.3.6 Prognosis 15
4.3.7 Treatment Options 15
4.4 Diabetic Retinopathies 16
4.4.1 Disease Overview 16
4.4.2 Signs and Symptoms 16
4.4.3 Epidemiology and Etiology 16
4.4.4 Pathophysiology 16
4.4.5 Diagnosis and Staging 17
4.4.6 Prognosis 17
4.4.7 Treatment Options 17
4.5 Overview of Marketed Products in Diabetic Complications 18
4.5.1 Overview of Marketed Products in Diabetic Neuropathies 18
4.5.2 Overview of Marketed Products in Diabetic Nephropathy 20
4.5.3 Overview of Marketed Products in Diabetic Retinopathies 20
5 Assessment of Pipeline Product Innovation 22......

List of Tables and Figures 
Table 1: Natural Development of Diabetic Nephropathy 15
Table 2: Diabetic Complications, Global, Data for NADPH Oxidase 4 as Therapeutic Target, 2016 44
Table 3: Diabetic Complications, Global, Data for Glutamate Decarboxylase as Therapeutic Target, 2016 46
Table 4: Diabetic Complications, Global, Data for Growth Hormone Secretagogue Receptor Type 1 as Therapeutic Target, 2016 47
Table 5: Diabetic Complications, Global, Data for Motilin Receptor as Therapeutic Target, 2016 48
Table 6: Diabetic Complications, Global, Data for Lysophosphatidic Acid Receptor 1 as Therapeutic Target, 2016 49
Figure 1: Diabetic Complications, Global, Number of Product Approvals by FDA and Five-Year Moving Average of Product Approvals (%), 1987–2012 6
Figure 2: Global, Sales Performance of First-in-Class and Non-First-in-Class Products after Marketing Approval ($m), 2016 8
Figure3: Diabetic Neuropathies, Global, Overview of Marketed Products, 2016 19
Figure 4: Diabetic Nephropathy, Global, Overview of Marketed Products, 2016 .....

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Last Updated December 14, 2016